迷走神经在心律失常发生中的研究进展

Role of vagal nerve in cardiac arrhythmia

作为遗传性心律失常之一的长QT综合征(LQTS),现已发现有12型,其中在中国以LQT2为常见,可诱发尖端扭转型室性心动过速及室颤,临床上以反复发作的晕厥及常导致的猝死为特征。自主神经通过释放神经递质作用于受体调节离子通道,从而对某些心律失常起到一定的作用,而迷走神经通过直接或间接作用对多种心律失常具有一定的保护作用。本文主要对LQT2的研究进展、迷走神经与LQT2的关系以及其在心律失常中发挥的作用作一综述。

As one of the familial abnormalities of cardiac rhythm, Long QT syndrome （LQTS） has been found in 12 different genes. LQT2 is one of the most common LQTS in China, which can lead to Torsade de Points （TdP） and ventricular fibrillation （VF）. Clinically it is characterized by recurrent syncope and sudden cardiac death. The autonomic nervous system plays a vital role in some cases of cardiac arrhythmia through the release of neurotransmitter to regulate ion channel. Recently, studies have shown that vagal nerve can reduce the occurrence of certain kinds of cardiac arrhythmia and may play an important role in maintaining normal cardiac rhythm and rate. This paper mainly reviews the recent advances of LQT2, the complex relationship between vagal nerve and LQT2, and the role of vagal nerve in cardiac arrhythmia.