摘要
SHP-2作为一种蛋白酪氨酸磷酸酶,包含2个SH2结构域,由PTPN11基因编码,参与多种细胞信号转导通路。其突变与不同类型的白血病及实体瘤的发生关系密切。研究SHP-2的作用机制可能会对临床抗肿瘤治疗带来新的希望。
The Src homology-2 domain-containing phosphatase SHP-2 encoded by PTPN11 is an essential component in several signaling pathways.Different types of mutation in SHP-2 have been confirmed in several types of leukemia and solid tumors.Elucidation of the events underlying Shp2-evoked transformation may provide new insights into the novel targets for anti-cancer therapy.
出处
《浙江大学学报(医学版)》
CAS
CSCD
北大核心
2012年第5期581-585,共5页
Journal of Zhejiang University(Medical Sciences)
关键词
蛋白质酪氨酸磷酸酶类/药理学
信号传导
磷酰化
肿瘤
白血病
Protein tyrosine phosphatases/pharmacology
Signal transduction
Phosphorylation
Neoplasms
Leukemia