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蛋白酪氨酸磷酸酶SHP-2研究进展 被引量：4

Research progress of protein tyrosine phosphatase SHP-2
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摘要 SHP-2作为一种蛋白酪氨酸磷酸酶,包含2个SH2结构域,由PTPN11基因编码,参与多种细胞信号转导通路。其突变与不同类型的白血病及实体瘤的发生关系密切。研究SHP-2的作用机制可能会对临床抗肿瘤治疗带来新的希望。 The Src homology-2 domain-containing phosphatase SHP-2 encoded by PTPN11 is an essential component in several signaling pathways.Different types of mutation in SHP-2 have been confirmed in several types of leukemia and solid tumors.Elucidation of the events underlying Shp2-evoked transformation may provide new insights into the novel targets for anti-cancer therapy.
作者 蔡洪科 邓甬川(综述)
机构地区 浙江大学医学院第二附属医院肿瘤外科
出处 《浙江大学学报（医学版）》 CAS CSCD 北大核心 2012年第5期581-585,共5页 Journal of Zhejiang University(Medical Sciences)
关键词 蛋白质酪氨酸磷酸酶类/药理学 信号传导 磷酰化 肿瘤 白血病 Protein tyrosine phosphatases/pharmacology Signal transduction Phosphorylation Neoplasms Leukemia
分类号 R730.2 [医药卫生—肿瘤]
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参考文献35

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浙江大学学报（医学版）
2012年 第5期

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