川芎嗪治疗不稳定型心绞痛疗效观察

Clinical effect of Ligustraxine in treatment of unstable angina pectoris

目的 研究川芎嗪对冠心病不稳定型心绞痛的疗效。方法 采用川芎嗪注射液 16 0mg加入 5 %葡萄糖 2 5 0ml静滴 ,每日 1次 ,观察临床表现及心电图变化 ,并与对照组传统疗法比较。结果 川芎嗪组有效率 90 % ,有效时间 8.3± 1.4天 ;对照组有效率 89% ,有效时间 10 .4± 1.0天 ,两组相比疗效无明显差异 (P <0 .0 5 ) ,有效时间川芎嗪组明显缩短 (P >0 .0 1)。结论 川芎嗪注射液可做为一种治疗冠心病不稳定型心绞痛的一种新方法。

Objective To observe the clinical efficacy of ligustrazine injection in the treatment of unstable angina pectoris (UPA). Methods A randomized controlled clinical trail was conducted. A total of 100 patients entered the study, with 50 in the Ligustrazine group and the remaining 50 in the control group. The Ligustrazine group received treatment with Ligustrazine(160mg/d). the other group received traditional treatment. The effects of both treatments at the end of the second week were compared. Result The total effective rate of two groups were 90% and 89% respectively . There was no difference between two groups ( P >0.05).The effective time of two groups was 8.3±1.4 days vs 10.4±1.0 days. There was obvious difference between two groups. The effective period in the Ligustrazine group was shorter than that in the other. ( P <0.01). Conclusion Ligustrazine injection can be a new way in the treatment of UPA.