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伊立替康疗效相关生物标志的研究进展 被引量：2

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摘要 0引言 喜树碱人工半合成物伊立替康（Irinotecan，CPT-11）是近10年来一种重要的抗肿瘤药物，被用于食管癌、胃癌、结直肠癌、肺癌、卵巢癌等多种肿瘤的治疗中。
作者 邹征云 沈洁 刘宝瑞
机构地区 南京大学医学院附属鼓楼医院肿瘤中心
出处 《癌症进展》 2012年第5期498-501,共4页 Oncology Progress
关键词 伊立替康 个体化疗 生物标志
分类号 R730.53 [医药卫生—肿瘤]
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参考文献19

  • 1Elisabeth Rouits, Miche'le Boisdron-Cellc, Agne's Du- mont, et al. Relevance of Different UGT1A1 Polymor- phisms in Irinotecan-Induced Toxicity: A Molecular and Clinical Study of 75 Patients [ J ]. Clinical Cancer Re- search, 2004, 10 (15):5151 -5159.
  • 2Leslie E. Carlini, Neal J. Meropol, John Bever, et al. UGT1A7 and UGT1A9 Polymorphisms Predict Response and Toxicity in Colorectal Cancer Patients Treated with Capeeitabine/Irinotecan [ J]. Clinical Cancer Research, 2005, 11 (3):1226-1236.
  • 3Hoskins J M, Goldberg R M, Qu P, et al. UGT1A1 * 28 genotype and irinotecan-induced neutropenia: dose matters [J]. J Natl Cancer Inst, 2007, 99 (17): 1290 - 1295.
  • 4Darren J. Burgess, Jason Doles, Lars Zender, et al. Topoi- somerase levels determine chemotherapy response in vitro and in vivo [J]. PNAS, 2008, 105 (26):9053 -9058.
  • 5Michael S. Braun, Susan D. Richman, Philip Quirke, et al. Predictive Biomarkers of Chemotherapy Efficacy in Colorectal Cancer: Results From the UK MRC FOCUS Tri- al [J]. J Clin Oncol, 2008, 26 (16):2690-2698.
  • 6Boonsong A, Curran S, McKay JA, et al. Topoisomerase I protein expression in primary colorectal cancer and lymph node metastases [J]. Hum Pathd, 2332, 33 (1U:ll14-1n9.
  • 7Koopman M, Knijn N, Richman S, et al. The correlation between topoisomerase-I ( Topol ) expression and outcome of treatment with capecitabine and irinotecan in advanced colorectal cancer ( ACC ) patients ( pts ) treated in the CAIRO study of the Dutch Colorectal Cancer Group ( DC-CG) [J]. EurJCancer, 2009, 7: 321.
  • 8Zhang YW, Regairaz M, Seiler JA, et al. Poly ( ADP-ri- bose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells [ J ]. Nucleic Acids Res, 2011, 39 (9): 3607 -3620.
  • 9Hoskins JM, Marcuello E, Ahes A, et al. Irinotecan phar- macogenetics : influence of pharmacodynamic genes [ J ]. Clin Cancer Res, 2008, 14 (6): 1788 - 1796.
  • 10Higinio Dopeso, Silvia Mateo-Lozano, Elena Elez, et al. Aprataxin Tumor Levels Predict Response of Colorectal Cancer Patients to Irinotecan-based Treatment [ J]. Clin Cancer Res, 2010, 16 (8) : 2375 - 2382.

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癌症进展
2012年 第5期

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