腰麻联合硬膜外麻醉下应用贺斯预防低血压的临床研究

Clinic study of hetastarch for prevention of hypotention during combined spinal and epidural anesthesia

目的 :比较 6 0 ml/ L 贺斯 (HES)和乳酸林格氏液对预防腰麻联合硬膜外麻醉 (CESA)下低血压的作用。方法 :CESA择期行妇科手术患者 2 2例 ,随机分为两组 ,静脉输注 6 0 ml/ L 贺斯或乳酸林格氏液 5 0 0 ml,观察收缩压(SBP)、舒张压 (DBP)、心率 (HR)和脉搏血氧饱和度 (SPO2 )的变化。结果 :两组患者上述指标基本稳定 ,与基础值相比 ,差异不显著 (P>0 .0 5 )。结论 :输注 6 0 ml/ L 贺斯或乳酸林格氏液均能有效地防止 CESA后血压降低 。

AIM: The purpose of this study was to compared the efficacy of 60 ml/L hetastarch in saline(HES) versus lactated ringer's solution for prevention of hypotention during combined spinal and epidural anesthesia(CESA). METHODS: 22 patients classified as ASA status Ⅰ Ⅱ who were scheduled for hysterectomy under CESA were enrolled in this study. They were randomized into two groups to infuse 500 ml 60 ml/L HES or 500 ml lactated ringer's solution, The variety of systolic blood pressure (SBP), diastolic blood pressure(DBP), heart rate(HR) and oxyhemoglobin saturation were monitored. RESULTS: Both groups were equally effective in preventing hypotention and the hemodynamic values were stable compared with the baseline. There were no significant difference( P >0.05). CONCLUSION:infusion of 500 ml HES or 500 ml ringer's solution intravenously was an effective prevention for ESCA induced hypotension, There was no different between HES and ringer's solution.