胃癌中EGFR、HER2、COX-2及GST-π的表达及意义

Expressions and significance of EGFR,HER2,COX-2 and GST-π in human gastric Carcinoma

目的 探讨胃癌组织中人表皮生长因子受体（EGFR）、表皮生长因子受体-2（HER2）、环氧合酶-2（COX-2）和胎盘型谷胱甘肽-S-转移酶-π（GST-π）的表达及与临床病理特征的关系.方法 应用免疫组化Envision 二步法,检测70例胃癌组织EGFR、HER2、COX-2及GST-π的表达情况,并结合其临床病理特点进行分析.结果 EGFR、HER2、COX-2及GST-π在胃癌组织中的表达阳性率分别为 35.7%、27.1%、67.1%和 58.6%.阳性表达与肿瘤分化程度、侵袭深度、有无淋巴结转移及TNM分期有关（P〈0.05）,而与患者的性别及年龄、肿瘤部位和大小无关（P〉0.05）.EGFR、HER2、COX-2及GST-π四者之间在胃癌组织中的表达均呈正相关（P〈0.05）.结论 EGFR、HER2、COX-2及GST-π的表达参与胃癌的生长、侵袭和转移过程.它们的联合检测有助于胃癌患者靶向药物联合化疗药物的初筛及对胃癌患者的预后评价.

Objective To investigate the expressions of EGFR,HER2, COX-2 and GST-~r in hu- man gastric carcinoma and study their relationship with clinicopathological factors of gastric carcinoma. Methods EnVision immunohistochemical stain was used to detect the expressions of EGFR, HER2, COX-2 and GST-π protein in gastric carcinoma tissues （70 samples）. All corresponding clinical data were retrospectively analyzed to explore the clinicopathological factors. Results The positive expression rates of EGFR,HER2,COX-2 and GST-π protein in gastric carcinoma tissues were 35.7% ,27.1% ,67.1% and 58.6% respectively. The positive expression rates were closely related to the differentiation of the carcino- ma,invasion depth, lymphatic metastasis and TNM stages （ P 〈 0.05 ）, but not to the patients ＇ sex, age, tumor location and tumor size （ P 〉 0.05 ）. There was a stable positive correlation among the expressions of EGFR, HER2, COX-2 and GST-πin gastric carcinoma tissues. Conclusion The expressions of EGFR, HER2, COX-2 and GST-π participate in the development ,invasion and metastasis process of gastric carci-noma. Joint detection of them may be helpful in judging the prognosis and guiding the molecular targeting therapy and chemotherapy of gastric carcinoma.