上海市儿童甲型H1N1流感病毒裂解疫苗接种不良反应评价

Evaluation of the Adverse Effects of Influenza Virus A(H1N1) Split Vaccine in Children and Adolescents in Shanghai

目的:探讨上海市儿童接种国产甲型H1N1流感病毒裂解疫苗不良反应发生情况。方法:对本市中小学生接种甲型H1N1流感病毒裂解疫苗后,发生不良反应并来我院就诊的192例儿童进行观察记录。结果:所观察的发生不良反应的儿童中,男∶女比例为1.23∶1,年龄6～15岁。192例儿童患者中,接种当天和接种后第1天发生不良反应的分别为72例(37.5%)和70例(36.5%)。临床症状含发热的儿童176例(91.7%),高热51例。以全身伴呼吸系统症状的儿童最多,为181人。在明确记录恢复时间的149例儿童中,以就诊后3 d内恢复的为主,为101例(67.8%)。结论:国产甲型H1N1流感病毒裂解疫苗接种儿童后未出现严重不良反应,安全性较高。

Objective：To discuss the safety and occurrence of adverse reaction（ADR） of influenza virus A（H1N1） split vaccine after it had been used in children and adolescents in Shanghai. Methods：192 subjects with ADRs who had their H1N1 vaccine inoculation in our hospital were reviewed and recorded and their recovering process,followed up. Results：Among the children and adolescents（aged 6-15 years） with ADRs,gender ratio（M/F） was 1.23：1.In the 192 subjects with clear record of ADR occurring time,72（37.5%） occurred exactly on the day of while 70（36.5%） occurred on the day after vaccination.Fever was the most common clinical symptom（176,91.7%） and sometimes it could even be hyperpyrexia（51）.Fever and respiratory symptoms occupied the maximum proportion among all kinds of ADRs.In 149 children and adolescents with clear record of recovery time,the majority（101,67.8%） were cured in 3 days after their visiting hospital.Conclusion：No severe adverse effects were found after the inoculation of domestic produced influenza virus A（H1N1） split vaccine,and it had its high safety in Chinese children and adolescents.