碱促进的新颖苯并呋喃类化合物的合成

A Novel Strategy for the Synthesis of Benzofuran Derivatives

水杨醛或水杨酮类化合物与溴代巴豆酸甲酯在N,N'-二甲基甲酰胺溶液中,以碳酸铯为碱,在70℃下一步生成苯并呋喃类化合物,产率中等到良好.产物的双键构型通过单晶衍射确定为E-式构型,所有目标化合物都通过核磁共振谱和高分辨质谱对其结构进行了确证.

A novel method for the synthesis of benzofuran analogues via condensation of 2-hydroxybenzaldehyde or 2-hydroxyphenyl ketone with methyl 4-bromocrotonate was reported. Moderate to good yield was obtained with cesium car- bonate as base in DMF at 70 ℃ The new-generated double bond was （E）-configuration determined by X-ray diffraction. All benzofuran derivatives were determined by 1H NMR, 13C NMR and HRMS techniques.