化学与生物转化法合成帕立骨化醇

Novel Synthesis of Paricalcitol by Chem-biotransformation

以维生素D2(1)为原料,通过七步有机合成反应和一次生物转化,成功获得了帕立骨化醇9,并得到了一条新的合成帕立骨化醇的路线,收率为3.24%.该合成方法路线短,操作简便,收率较文献中的方法有较大提高.所有产物结构经1H NMR,13C NMR和MS表征.

Paricalcitol （9） was obtained from Vitamin D2 via a route of the combination of seven-step organic reaction and biotransformation. The overall yield was 3.24%, which was higher than those of the reported methods. The structures of all intermediates and product were confirmed by 1H NMR, 13C NMR and MS techniques.