壳聚糖/聚乳酸复合纳米纤维的制备及抗菌性能研究

Preparation and Antibacterial Performance of CS/PLA Composite Nanofiber Films

采用静电纺丝技术制备聚乳酸(PLA)质量分数为8%的纳米纤维及壳聚糖(CS)与聚乳酸(PLA)质量比为1/5、1/10、1/15、1/20、1/40的复合纳米纤维。借助扫描电子显微镜(SEM)观察和红外光谱(FT-IR)分析,并利用振荡烧瓶法测试抗菌性能。结果表明:CS的含量对纳米纤维的形态影响很大,且PLA与CS能很好地复合;复合纳米纤维对大肠杆菌和金黄色葡萄球菌有良好的抗菌作用,当CS与PLA质量比大于1/10时,对2种菌的抑菌率达90%以上。

Polylactide（PLA） nanofiber films with mass fraction 8% and chitosan（CS）-PI.A composite films with differerent mass ratios of CS to PLA（1/5,1/10,1/15,1/20,1/40） were prepared via electrospinning. The films were characterized by scanning electron microscope（SEM） and infrared spectroscopy（IR） ,and oscillation flask method was used to test antibacterial performance. It is found that the chitosaa content affects the morphology of nanofibers availably, and PLA and CS can be composited very well; CS/PLA composite membrane has good antibacterial effect on Escherichia coli and Staphylococcus aureus, and the bacterial inhibition rate is above 90 % when the mass ratio of CS to PLA is greater than 1/10.