高血压病患者瘦素与胰岛素抵抗及炎症的相关性研究

Study on the relationship of serum leptin level with insulin resistance and inflammation in primary hypertensive patients

目的探讨高血压病患者血清瘦素水平与胰岛素抵抗及炎症的关系。方法选择50例无糖尿病病史的高血压病患者(高血压组)和40例体检正常者(对照组)。收集一般资料,测量血压、腰围、身高、体重等,收集空腹静脉血,测定血脂,空腹血糖,空腹胰岛素,超敏C-反应蛋白(hsCRP)及瘦素等。用胰岛素抵抗指数(IRI)作为胰岛素敏感性评价指标。结果高血压病患者的有关临床资料进行统计分析,结果显示:体重指数,腰围,胰岛素,胰岛素抵抗指数,超敏C-反应蛋白及血清瘦素在高血压组和对照组之间的差异有统计学意义(P<0.05)。经Person相关分析发现高血压组患者血清瘦素水平与腰围,IRI,hsCRP呈正相关(P<0.05),对照组血清瘦素水平与IRI,hsCRP呈正相关(P均<0.05)。结论高血压病患者存在高瘦素血症或者瘦素抵抗,且高瘦素血症或者瘦素抵抗与胰岛素抵抗及炎症状态密切相关。

Objective To study the relationship of serum leptin level with insulin resistance and inflammation in Primary Hyperten- sive patients. Methods The basic information was collected in 50 hypertensive patients without diabetic history and 40 normal control. Blood pressure, waist circumference , height and body weight were measured. Then blood samples were taken from them for measurement of biochemi- cal indicators. Fasting Serum Leptin was tested by enzyme linked immunosorbent assay （ELISA）. Insulin resistance index（IRI） was applied to estimate insulin resistance. Results The levels of waist circumference, IRI, hsCRP and Serum leptin were significantly higher in the hy- pertensive patients than those in control group（P 〈 0. 05）. Pearson relation analysis showed that the leptin level of the hypertensive patients was positively correlated with waist circumference, IRI and hsCRP（ P 〈 0. 05 ）. In normal control group, the leptin level was positively correla- ted with IRI and hsCRP（ P 〈 0. 05 ）. Conclusion The results suggest that hyperleptinemia or leptin resistance was found in hypertensive pa- tients. Furthermore, hypedeptinemia or leptin resistance is significantly correlated with systemic inflammation and insulin resistance.