氧化应激与胰岛素抵抗分子机制之联系

Interaction between oxidative stress and molecular mechanisms of insulin resistance

氧化应激是体内活性氧化物产生多于清除的氧化还原反应失衡的病理状态。对胰岛素抵抗的发生发展起着关键性作用。本文综述了氧化应激致胰岛素抵抗的信号传导途径,旨在为胰岛素抵抗相关疾病的抗氧化药物治疗及信号途径药物干预治疗提供新的途径或靶点。

Oxidative stress is defined as a serious imbalance between the production of reactive species and antioxidant defenses,leading to potential tissue damage.It may play a key role in the insulin resistance.This paper reviews how oxidative stress can block insulin signaling pathway and lead to insulin resistance.A full understanding of the link between oxidation and insulin resistance should beneficial for appropriate management of insulin resistance by antioxidatin.