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糖皮质激素全身应用与局部吸入序贯疗法对哮喘患者的疗效观察 被引量:14

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摘要 目的对比观察糖皮质激素全身应用、局部雾化吸入及两者序贯应用在治疗中重度哮喘患者中的疗效。方法中重度哮喘急性发作期患者120例随机分为A、B、C 3组,A组给予全程全身糖皮质激素治疗;B组先全身应用再局部雾化吸入糖皮质激素;C组全程局部雾化吸入糖皮质激素。余治疗包括常规对症、吸氧等。治疗7天后,评价患者临床疗效,测定患者肺功能(FEV1占预计值/%、FEV1/FVC/%)及诱导痰EOS、ECP值。结果序贯应用治疗组总有效率明显高于其他治疗组(P<0.05),肺功能的改善程度高于其他组(P<0.05),能降低诱导痰EOS、ECP水平与对照组组有显著性差异(P<0.05)。结论糖皮质激素全身与局部雾化吸入序贯应用较单一全身应用或单一局部雾化吸入床症状缓解更加迅速,肺功能改善明显,炎症控制更理想,不良反应少,值得推广。
出处 《海峡药学》 2012年第9期87-88,共2页 Strait Pharmaceutical Journal
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  • 1孔炜,储小彬,张喻,宋磊.RSV毛细支气管炎后早期干预对哮喘发病率的影响[J].中国交通医学杂志,2005,19(5):519-520. 被引量:5
  • 2李泽庚,张杰根,彭波,张念志,韩明向.肺气虚证和肺阴虚证患者外周血T细胞的变化[J].中国中医药科技,2006,13(1). 被引量:21
  • 3沈晓明.儿科学[M].第7版,北京.人民卫生出版社,2008:265-266.
  • 4Kita H.The eosinophil a cytokine-producing cell[J].J Allergy Clin Immunol,1997,97 (4):889-892.
  • 5Sacco O, Sale R, Silvestri M, et al. Total and allergen-specific IgE levels in serum reflect blood eosinophilia and fractional exhaled nitric oxide concentrations but not pulmonary functions in allergic asthmatic children sensitized to house dust mites. Pediatr Allergy Immunol. 2003,14: 475-481.
  • 6Siroux V, Oryszczyn MP, Paty E, et al. Relationships of allergic sensitization, total immunoglobulin E and blood eosinophils to asthma severity in children of the EGEA Study. Clin Exp Allergy, 2003, 33:746-751.
  • 7Di Gioacchino M, Cavallucci E, Di Stefano F, et al. Influence of total IgE and seasonal increase of eosinophil cationic protein on bronchial hyperreactivity in asthmatic grass-sensitized farmers. Allergy, 2000,55: 1030-1034.
  • 8Crawford WW, Gowda VC, Klaustermeyer WB. Age effects on objective measures of atopy in adult asthma and rhinitis. Allergy Asthma Proc,2004, 25: 175-179.
  • 9Huss K, Adkinson NF Jr, Eggleston PA, et al. House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the Childhood Asthma Management Program. J ALlergy Clin Immunol, 2001, 107: 48-54.
  • 10Kerkhof M, Dubois AE, Postma DS, et al. Role and interpretation of total serum IgE measurements in the diagnosis of alleqgic airway disease in adults. Allergy, 2003, 58: 905-911.

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  • 1陈谱,何韶衡.支气管哮喘的病理学研究进展[J].中华儿科杂志,2005,43(3):235-238. 被引量:17
  • 2中华医学会儿科学分会呼吸学组呼吸分会.支气管哮喘诊断与防治指南.中华儿科杂志,2008,46(10):746-748.
  • 3粱吉斌.糖皮质激素对老年支气管哮喘患者生命质量的影响[J].内蒙占中医药,2012,31(17):23-24.
  • 4孙树梅,谢松敏.布地奈德溶液雾化吸入治疗对喘息性支气管炎患儿呼吸道阻力的影响[J].实用儿科临床杂志,2007,22(4):299-300. 被引量:49
  • 5张娟.头孢哌酮钠/舒巴坦钠治疗下呼吸道感染疗效观察[J].中外健康文摘,2013,10(24):237-238.
  • 6Chau JP, Lee DT, Yu DS, et al. A feasibility study to investigate the acceptability and potential effectiveness of a telecare service for older people with chronic obstructive pulmonary dlsease[J]. Int J Med Inform, 2012,81 (10) : 674- 682.
  • 7Gao Y,Du X, Liang L, et al. Evaluation of right ventricular funetion by 64-row CT in patients with ehronieobstruetive pulmonary disease and eor pulmonale[J]. Eur J Radiol,2012, 81 (2) : 345-353.
  • 8蔡燕,林黎娟,王群东,等.糖皮质激素与长效β受体激动剂联合使用治疗成人哮喘临床研究[J].医学信息,2013(17):569.
  • 9Zhang Y, Li W, Yan T, et al. Early detection of lesions of dorsal artery of foot in patients with type 2 diabetes mellitus by high-freq uency uhrasono graphy. J Huazhong Univ Sci Technolog Med Sci ,2011,29:387-390.
  • 10Vestbo J, Hurd SS, Agusti AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med,2013,187:347- 365.

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