摘要
目的:探讨胃癌患者手术前后血清IGF-Ⅱ、TGF-α和TNF-α水平的变化及临床意义。方法:应用放射免疫分析对31例胃癌患者进行了手术治疗前后血清IGF-Ⅱ、TGF-α和TNF-α检测,并与35名正常健康人作比较。结果:胃癌患者在手术治疗前血清IGF-Ⅱ、TGF-α和TNF-α水平非常显著地高于正常人组(P<0.01)。经手术治疗3个月后则与正常人组比较无显著性差异(P>0.05)。结论:检测胃癌患者血清IGF-Ⅱ、TGF-α和TNF-α水平的变化可作为疗效观察的指标。
Objective To explore the significance of changes of serum IGF-Ⅱ,TGF-α and TNF-α levels both before and after operation in patients with gastric cancer.Methods Serum IGF-Ⅱ,TGF-α and TNF-α levels were determined with RIA in 31 patients with gastric cancer and 35 normal healthy controls.Results Before operation,the serum IGF-Ⅱ,TGF-α and TNF-α levels in the patients were significantly higher than those in the controls（P0.05）.Conclusion Serum levels of IGF-Ⅱ,TGF-α and TNF-α might be useful as an indicalor for predicting therapeutic efficacy after operation in patients with gastric cancer.
出处
《放射免疫学杂志》
CAS
2012年第5期497-499,共3页
Journal of Radioimmanology
关键词
胃癌
胰岛素样生长因子-Ⅱ
转化生长因子-Α
肿瘤坏死因子-Α
gastric cancer
insulin-like growth factor-Ⅱ（IGF-Ⅱ）
transforming growth factor-α（TGF-α）
tumor necrosis factor-α（TNF-α）
