妊高征肾病患者血浆ET-1和血清TGF-β1、IL-10检测及其临床意义

Clinical Significance of Determination of Changes on Plasma ET-1 and Serum TGF-β_1,IL-10 Levels in Patients with Pregnancy Induced Hypertension Complicated with Nephropathy

目的:探讨妊高征肾病患者治疗前后血浆ET-1和血清TGF-β1、IL-10水平的变化及临床意义。方法:应用放射免疫分析和酶联法对32例妊高征肾病患者进行了治疗前后血浆ET-1和血清TGF-β1、IL-10检测,并与35名正常人作比较。结果:妊高征肾病患者在治疗前血浆ET-1和血清TGF-β1、IL-10均非常显著地高于正常人组(P<0.01),经治疗2周后则与正常人组比较无显著性差异(P>0.05),血浆ET-1和血清TGF-β1、IL-10水平呈正相关(r=0.4812、0.5784,P<0.01)结论:检测妊高征肾病患者血浆ET-1和血清TGF-β1、IL-10水平的变化,对患者的病情判断、疗效观察具有重要的临床价值。

Objective To explore the clinical significance of determination of changes on plasma ET-1 and serum TGF-β1,IL-10 levels after treatment in patients with pregnancy induced hypertension complicated with nephropathy.Methods Plasma ET-1 and serum IL-10（with RIA）,serum TGF-β1（with ELISA） levels were measured in 32 patients and compared with 35 normal controls.Results Before treatment plasma ET-1 and serum TGF-β1,IL-10 levels were significantly higher than those in controls（P0.05）,plasma ET-1 level was positively correlated with TGF-β1,IL-10 levels（r=0.4812,0.5784,P〈0.01）.Conclusion Estimation of plasma ET-1 and serum TGF-β1,IL-10 levels might be useful for clinical diagnosis and predicting therapeutic effects in patients with PIH,and provides definite clinical value.