妊高征肾病患者血清CysC、TGF-β_1和HGF检测的临床意义

Clinical Significance of Measurement of Changes of Serum CysC,TGF-β_1 and HGF Levels in Patients with Pregnancy Induced Hypertension Complicated with Nephropathy

目的:探讨了妊高征肾病患者血清CysC、TGF-β1和HGF水平的变化及临床意义。方法:应用胶乳免疫增强比浊法和酶联法对38例妊高征肾病患者进行了血清CysC、TGF-β1和HGF检测,并与35名正常健康人作比较。结果:妊高征患者血清CysC、TGF-β1和HGF水平均非常显著地高于正常人组(P<0.01),且血清CysC水平与TGF-β1和HGF水平呈正相关(r=0.6012、0.5784,P<0.01)。结论:检测妊高征肾病患者血清CysC、TGF-β1和HGF水平的变化对了解病情、观察疗效和预后判断均有一定的临床价值。

Objective To explore the clinical relevance of measurement the changes on serum CysC,TGF-β1 and HGF levels in patients pregnancy induced hypertension complicated with nephropathy.Methods Serum CysC（with latex-enhanced immunoturbidimetry）,serum TGF-β1 HGF（with ELISA） levels were determined in 38 patients with pregnancy induced hypertension complicated wite mephropathy and 35 normal healthy controls.Results Serum CysC,TGF-β1 and HGF levels in these patients were significantly higher than those in controls（P〈0.01）.Serum CysC level was positively correlated with serum TGF-β1 and HGF（r=0.612,0.5784,P〈0.01）.Conclusion Changes of serum CysC,TGF-β1 and HGF levels might be of prognostic inportance in patients with pregnancy induced hypertension complicated with nephropathy.