大连市儿童医院351例儿童药物不良反应回顾性分析

Retrospective Analysis on 351 Adverse Drug Reaction Cases

目的:对儿童药物不良反应(ADR)的基本情况和发生特点进行分析总结。方法:对2009年至2011年我院上报给国家药品不良反应监测网的351例ADR报告进行回顾性统计分析。结果:男222例,女129例;1～3岁幼儿发生ADR的比例最高(38.50%);静脉滴注引起的ADR比例最高(79.45%);皮肤及附件损害为最主要的ADR,占75.50%;抗生素和中药注射剂引起的ADR占较高比例。结论:应加强儿科不良反应监测工作,保障患儿安全用药。

Objective： To analyze and summarize the status and characteristics of adverse drug reactions in pediatrics. Methods： Retrospectively analyzed 351 ADR reports to National Adverse Drug Reaction Monitoring Network by Dalian Children＇ s Hospital during 2009 to 2011. Results： There were 222 male cases and 129 female cases, ADR rate of children within 1 - 3 years were highest, percentage in each group were more than 38.50%. Most ADR were caused by intravenous infusion; the main reaction was appendages of skin injuries with a percentage of 75. 50%. Top medicines ranked in the list were antibiotics and Chinese medicine injections. Conclusions： The pediatric adverse drug reaction has some unique features. The monitoring and reporting of pediatric ADR should be strengthened persistently, in order to protect the health of children, reduce its incidence and decrease their mortality.