体外循环围手术期患者血浆内皮素浓度变化及抑肽酶对其的影响

Changes of Endothelin Content in the Perioperative Period of Cardiopulmonary Bypass and the Role of Aprotinin

目的 :研究体外循环 (CPB)心脏直视手术围手术期血浆内皮素 (ET)浓度的变化及抑肽酶对其影响和可能的机制。方法 :2 4例患者随机分为对照组 ( 12例 )与实验组 ( 12例 )。实验组患者给予抑肽酶。手术前后分 7个时点采桡动脉血供放射免疫检测。结果 :对照组血浆ET含量明显增加 ,而在手术前后实验组血浆ET含量显著低于对照组 (P <0 .0 1)结论 :抑肽酶可显著降低血浆ET的含量 。

Objective The purpose of the investigation was to study the perioperative changes in endothelin(ET) content in cardiopulmonary bypass(CPB),the effect of aprotinin on them and the possible mechanism.Method Twenty four patients were randomly divided into two groups:control group( n =12) and experimental group( n =12).The patients in the experimental group were administered aprotinin.Blood samples were obtained from the radial artery at seven intervals in perioperation for radioimmunoassay of ET.Results In the control group,the ET content was significantly increased,but it was significantly lower in the experimental group than in the control group during the period of post CPB( P <0.01).Conclusion Aprotinin can obviously reduce ET content and heart or lung injury induced by CPB.