六味地黄汤对氢化可的松模型小鼠的免疫调节作用

Immunomodulatory effects of Liu Wei Di Huan Tang on hydrocortisone model mice

目的 :为探讨六味地黄汤 ( L iu wei di huan tang L WDH T)对氢化可的松所致免疫功能低下模型小鼠免疫功能的影响。方法 :采用 MTT比色法等技术分别测定了氢化可的松所致免疫功能低下模型小鼠六味地黄汤治疗后免疫功能指标。结果 :六味地黄汤能不同程度地拮抗氢化可的松对小鼠腹腔 Mψ吞噬活性 ,脾脏淋巴细胞转化增殖 ,IL-2分泌 ,NK细胞活性的抑制。结论 :六味地黄汤能多途径增强氢化可的松所致免疫功能低下小鼠免疫功能。

Objective: To explore the immunomodulatory effects of Liuwei Dihuan Tang (LWDHT) on hydrocortisone model mice, phagocytosis of Mψ Methods: T Lymphocyte proliferation and transformation rate, activity of NK cell and production of IL 2 were respectively detemined after LWDHT treatment in hydrocortisone model mice by using MTT colorimetry technique. Results: The experimental results showed that LWDHT significantly enhanced phagocytosing function of Mψ, T Lymphocyte proliferation and transformation rate, activity of NK cell and production of IL 2 in/mice treated by hydrocortisone. Conclusion: These results indicated that LWDHT had the immunomodulatory effect in hypoimmune mice treated by hydrocortisone.