吡哌酸滴耳剂治疗化脓性中耳炎的临床观察

Pipemidic acid otic solution in the treatment of suppurative otitis media

目的 :观察吡哌酸滴耳剂治疗化脓性中耳炎的疗效。方法 :应用 0 .2 %吡哌酸滴耳剂治疗 40例慢性中耳炎患者 ,疗程 7d,分别于用药后第 3天和第 7天进行临床症状、体征及细菌学检查 ;同时用 0 .2 5%的氯霉素滴耳剂作对照。结果 :吡哌酸滴耳剂 3d后有效率和细菌清除率为 65%和 60 % ,7d后分别为 92 .5%和90 % ,氯霉素滴耳剂临床有效率和细菌清除率 3d为 42 .5%和 40 % ,7d后分别为 62 .5%和 60 % ,差异有显著性 (P<0 .0 1 )。结论 :吡哌酸滴耳剂治疗慢性化脓性中耳炎高效、安全。

Objective:To study the efficiency of pipemidic acid otic solution in treating suppurative otitis media.Method:Forty cases of suppurative otitis media were treated with pipemidic acid otic solution for seven days.Observation of clinical symptom,sign and bacteria was made after three days and seven days.Results:After three days the rate of clinical efficiency was 65%,of bacteriological eliminition was 60%,after seven days they were 92.5% and 90% respectively.Compared with the control group used 0.25% chloromycetin otic solution,the latter showed that the clinical efficiency and eliminition of bacteria were 42.5% and 40% respectively after three days,62.5% and 60% after seven days.There was significant difference between the two groups (P<0.01).Conclusion:Pipemidic acid otic solution is highly effective,safe and practical in treating suppurative otitis media.