对4386人的HbA_1c与其他相关指标关系的调查和分析

Survey and analysis of correlation of HbA_1c with other parameters in 4386 employees

目的通过调查4386名职工HbA1c水平,分析其与人体指标的相关关系。方法对4386名45岁以上企业职工进行HbA1c检测,并检测FPG、TC、TG、高敏C反应蛋白(hsC-RP)、WBC、中性粒细胞(NC)水平。结果 HbA1c男性为(5.52±0.79)%,女性为(5.49±0.63)%,男女比较差异无统计学意义(P>0.05);HbA1c与FPG的回归方程为:YHbA1c=0.541X+2.707,r=0.7679。以HbA1c≥6.5%标准诊断糖尿病,共检出糖尿病277例(6.32%),男女比例为2.46∶1。糖尿病人群TG、WBC、NC、hsC-RP与正常人群比较差异有统计学意义(P<0.05)。脂肪肝患者的HbA1c、FPG、TG水平显著高于正常人群(P<0.05)。结论以HbA1c≥6.5%为标准,4386名职工的糖尿病检出率为6.32%,高于以血糖为标准的糖尿病检出率。HbA1c、FPG水平随年龄的增长而增高,糖尿病患病率男性高于女性,HbA1c增高与TG、hsC-RP、WBC、NC及脂肪肝患病有关。

Objective To understand the HbA1c level and analyze its relationship with human physiological indexes.Methods The HbA1c level was measured in enterprise employees aged 45 years or more,using Japanese Tosoh HLC-723 G7 automatic glycohemoglobin analyzer,and the FPG,TC,TG,hsC-RP,WBC,NC（neutrophil count） were detected.Results The HbA1c was（5.52±0.79）% for 2783 males,and（5.49±0.63）% for 1603 females,with no significant difference in gender（P〉0.05）.The regression equation expressing the relation between HbA1c and FPG is： YHbA1c=0.541X＋2.707,r=0.7679.DM was diagnosed in 277 persons,accounting for 6.32% of the total subjects（n=4386）,with a male to female ratio of 2.46：1.There was a significant difference（P〈0.05） in TG,WBC,NC,and hsC-RP between DM and normal population.The HbA1c,FPG,and TG levels in fatty liver patients were significantly higher than in normal population.Conclusions HbA1c testing shows a higher DM detection rate than blood glucose testing.HbA1c and FPG levels increase along with ageing,and DM prevalence is higher in male than in females.HbA1c,TG,hsC-RP,WBC,and NC levels are related with fatty liver disease