血清CC亚族趋化因子配体20与2型糖尿病相关性的研究

Association of serum CCL20 with type 2 diabetes mellitus

目的探讨血清CC亚族趋化因子配体20(CCL20)的水平与T2DM和肥胖的关系。方法将82名正常对照(NC)组分为非肥胖组(A组)和肥胖组(B组),79例新诊断的T2DM患者分为非肥胖组(C组)和肥胖组(D组)。测量各组身高、体重、血压、WC、臀围,测定FPG、FIns、HbA1c、血尿酸(SUA)、TC、TG、HDL-C及LDL-C,计算BMI、WHR和胰岛素抵抗指数(HOMA-IR)。结果 D组血清CCL20的浓度较A组和B组升高(P<0.05)。相关分析显示,T2DM组中CCL20与UA和LDL-C呈正相关,与HDL-C呈显著负相关(P<0.05)。多元回归分析表明,LDL-C是血清CCL20的独立相关因素(P<0.01)。结论 CCL20与T2DM密切相关,可能参与了T2DM的发生和发展。

Objective To evaluate the association of serum chemokines CC ligand 20（CCL20） with T2DM.Methods Eighty-two subjects with normal glucose tolerance were divided into non-obesity group（A group） and obesity group（B group）,and 79 newly diagnosed T2DM patients were divided into non-obesity group（C group） and obesity group（D group）.Height,weight,blood pressure,fasting plasma glucose（FPG）,fasting insulin（FIns）,HbA1c,serum uric acid（UA）,total cholesterol（TC）,triglycerides（TG）,high density lipoprotein cholesterol（HDL-C）,and low density lipoprotein cholesterol（LDL-C） were determined in all subjects.Body mass index（BMI）,waist-to-hip ratio（WHR）,and homeostasis model assessment for insulin resistance index（HOMA-IR） were calculated.Results Compared with A group and B group,the levels of CCL20 in D group were significantly higher（P〈0.05）.Simple correlation analysis showed that in the T2DM group CCL20 was positively correlated with UA and LDL-C,but negatively with HDL-C（P〈0.05）.Furthermore,multiple regression analysis showed that LDL-C was the independent factor of serum CCL20 level（P〈0.01）.Conclusion CCL20 may play a role in the pathogenesis of T2DM