甲氨蝶呤联合米非司酮保守治疗异位妊娠的临床疗效

目的研究甲氨蝶呤联合米非司酮对异位妊娠的治疗效果。方法将2009年～2011年间收治的54例异位妊娠患者随机分为试验组和对照组,每组各27人,对照组单独应用米非司酮治疗,试验组应用甲氨蝶呤联合米非司酮治疗,对两组患者治疗效果进行评价和比较。结果对照组患者痊愈13例,有效8例,无效6例,总有效率为77.8%,试验组患者痊愈18例,有效8例,无效1例,总有效率为96.3%。试验组总有效率显著高于对照组(P<0.05)。对照组血β-绒毛膜促性腺激素(β-hCG)为(277±263)IU/L,试验组为(568±389)IU/L,试验组显著低于对照组(P<0.05)。结论甲氨蝶呤联合米非司酮治疗异位妊娠有效率高,不良反应少,是一种理想的保守治疗方案。

Objective To research the effectiveness of expectant therapy of methotrexate and mifepristone on ectopic pregnancy. Methods The 54 ectopic pregnancy patients during 2009 to 2011 were divided into control and experimental group randomLy. The control group was treated with mifepristone and the experimental group was treated with methotrexate and mifepristone. Results The control group had 13 patients cured, 8 improved and 6 inefficient while the experimental group had 18 cured, 8 improved and 1 inefficient. The experimental group had a significant higher cure rate than control group（P0.05）. And the experimental group had a significant lower β-hCG level of （277±263）IU/L than control group of （568±389）IU/L（P0.05）. Conclusion Methotrexate combined with mifepristone was a good expectant therapy of less side effect and higher cure rate on ectopic pregnancy.