麻疯树酚性成分研究

Phenolic compounds from Jatropha curcas

目的:研究麻疯树Jatropha curcas中的化学成分。方法:采用硅胶和HPLC等色谱手段进行化学成分的分离纯化,根据波谱数据鉴定化合物结构。结果:从麻疯树茎的甲醇提取物中分得14个酚性化学成分,其结构分别鉴定为5,4'-二甲羟基-3,7,3'-三甲氧基黄酮(1),5,3',4'-三羟基-3,7-二甲氧基黄酮(2),槲皮素-3-甲醚(3),5,6,7-三甲氧基香豆素(4),5-羟基-6,7-二甲氧基香豆素(5),异莨菪亭(6),ω-hydroxypropioquaiacone(7),松柏醛(8),3,5-二羟基-4-甲氧基苯甲醛(9),香草酸(10),异香草醛(11),对羟基苯甲醛(12),升麻素(13),(E)-3-羟基-5-甲氧基芪(14)。结论:化合物1～4,6～14为首次从该属植物中分离得到。

Objective： To determine the chemical constituents of Jatropha curcas. Method： Chemical constituents were ob- tained using various chromatography methods including silica gel column chromatography and HPLC. The structures of isolated com- pounds were determined by spectroscopic methods including J H-NMR, 13 C-NMR and MS. Result and Conclusion： Fourteen phenolic compounds were obtained from the stems of J. curcas and their structures were identified to be 5,4＇-dihydroxy-3,7,3＇-trimethoxyflavone （ 1 ） ,5,3＇,4＇-trihydroxy-3,7-dimethoxyflavone （ 2 ）, 3-O-methylquercetin （ 3 ）, 5,6,7-trimethoxycoumarin （ 4 ）, tomentin （ 5 ）, isoseopole- tin （ 6 ）, ω-hydroxypropioquaiacone （ 7 ）, coniferaldehyde （ 8 ）, 3,5-dihydroxy-4-methoxybenzaldehyde （ 9 ）, vanillic acid （ 10 ）, isovanillin （ 11 ） ,4-hydroxybenzaldehyde （ 12 ）, cimifugin （ 13 ） and （ E ） -3-hydroxy-5-methoxy-stilbene （ 14 ）. Among them, compounds 1-4 and 6-14 were isolated from the genus of Jatropha for the first time.