慢性咽炎咽部分泌物的病原菌分布及耐药性分析

Distribution and drug resistance of pathogens isolated from secretions of patients with chronic pharyngitis

目的探讨慢性咽炎患者咽部分泌物病原菌分布及耐药性,以指导临床合理用药。方法对2009年8月至2011年8月医院收治的200例慢性咽炎患者咽后壁分泌物进行细菌培养和药敏试验。结果 200例慢性咽炎患者的咽拭子标本中共检出病原菌517株,检出前3位分别为α-溶血性链球菌、副流感嗜血菌、表皮葡萄球菌,分别占19.92%、9.48%、8.32%;慢性咽炎病原菌对青霉素、红霉素、克林霉素、磺胺甲噁唑/甲氧苄啶的耐药率均>50.00%,分别为62.12%、60.78%、58.85%、54.94%。结论慢性咽炎患者咽部病原菌的检出率较高,为慢性咽炎的病因之一,治疗前应进行药敏试验以期合理选择抗菌药物。

OBJECTIVE To explore the distribution and drug resistance of the pathogenic bacteria isolated from the secretions of the patients with chronic pharyngitis so as to guide the clinically rational use of drugs.METHODS From Aug 2009 to Aug 2011,a total of 200 patients with chronic pharyngitis were enrolled in the study,the bacterial culture and the drug susceptibility testing were performed for the posterior pharyngeal secretions.RESULTS Of totally 517 strains of bacteria isolated from the throat swab specimens of 200 chronic pharyngitis,the α-hemolytic Streptococcus,Haemophilus parainfluenzae,and Staphylococcus epidermidis were the top 3 pathogens,accounting for 19.92%,9.48%,and 8.32%,respectively;the drug resistance rates of the isolates to penicillin,erythromycin,clindamycin,and sulfamethoxazole/trimethoprim were 62.12%,60.78%,58.85%,and 54.94%,respectively.CONCLUSION The isolation rate of the pathogens from the patients with chronic pharyngitis is high,the antibiotics should be used reasonably based on the drug susceptibility testing.