手足口病合并细菌感染的病原菌分布及耐药性分析

Pathogens for bacterial infections with hand,foot, and mouth diseases and analysis of drug resistance

目的探讨手足口病合并细菌感染的病原菌分布及其耐药性。方法选取2009年1月-2011年12月入住ICU的重症手足口病合并细菌感染的32例患儿为研究对象,将其分离出的病原菌分布及耐药性进行调查研究。结果 32例患儿共送检64份标本,检出34株病原菌,其中大肠埃希菌、鲍氏不动杆菌及铜绿假单胞菌所占比例最高,分别占41.18%、23.53%及17.65%,其中大肠埃希菌所占比例明显高于其他病原菌;3种病原菌的耐药率最高的3种抗菌药物为头孢噻肟、头孢吡肟、头孢他啶,分别为75.00%～83.33%、62.50%～71.43%、62.50%～66.67%,差异有统计学意义(P<0.05)。结论手足口病合并细菌感染的病原菌分布及耐药性均有其特点,在诊断及治疗的过程中应给予重视。

OBJECTIVE To investigate the distribution of bacterial infections of the hand,foot and mouth disease pathogens and situation of the antibiotic resistance.METHODS A total of 32 children with severe HFMD and bacterial infections from Jan 2009 to December 2011 admitted to the ICU were chosen as the research objects.The pathogen distribution and antibiotic resistance were taken for investigation.RESULTS There were 64 specimens in the 32 patients of submission,and 34 strains of pathogens were detected,including Escherichia coli,Acinetobacter baumannii and Pseudomonas aeruginosa,accounting for 41.18%,23.53% and 17.65%,the proportion of E.coli was significantly higher than that of the other pathogens.The three antibiotics with the highest drug resistance rates were cefotaxime sodium（75.00%～83.33%）,cefepime（62.50%～71.43）,and ceftazidime（62.50%～66.67%）,the differences were statistically significant（P0.05）.CONCLUSION The distribution and drug resistance of the the pathogens causing bacterial infections with the hand,foot and mouth diseases have their own characteristics,which should be attached great importance.