复治涂阳肺结核患者分枝杆菌属培养及药敏结果分析

Culture and antimicrobial susceptibility of Mycobacteria in recurrent pulmonary tuberculosis patients

目的了解衢州地区痰涂阳性肺结核患者对常用抗结核药物的耐药性,为临床用药提供依据。方法衢州地区的痰涂阳性复治肺结核142例患者送检的痰液进行分枝杆菌属培养和药敏试验,分析抗结核药物的耐药性。结果 85例获得菌种鉴定和有药物敏感试验结果者中结核分枝杆菌复合群82例,非结核分枝杆菌3例,82例结核分枝杆菌复合群中耐药47例,总耐药率57.32%。结核分枝杆菌对抗结核药物的耐药率依次为异烟肼45.12%、利福平39.02%、链霉素34.15%、氧氟沙星34.15%、乙胺丁醇12.20%、卡那霉素7.32%。结论衢州地区复治涂阳肺结核患者耐药性严重,应开展分枝杆菌属培养和药敏试验,并根据药敏结果组成治疗方案。

OBJECTIVE To learn the drug resistance to the antitubercular agents in the tuberculosis patients with sputum culture positive in Quzhou area so as to provide basis for the clinical medication.METHODS The Mycobacteria culture and the antimicrobial susceptibility testing were carried out for the submitted sputum from the 142 recurrent pulmonary tuberculosis patients with sputum culture positive,the drug resistance to the antitubercular agents was analyzed.RESULTS Totally 85 cases were subjected to the bacterial identification and the drug susceptibility testing,among which 82 cases were identified as MTBC,there were 47 cases with MTBC＇s drug resistance,the total drug resistance rate was 57.32%,3 cases were NTM.The drug resistance rates to INH,RIF,SM,OFLX,EMB,and KM were 45.12%,39.02%,34.15%,34.15%,12.20%,and 7.32%,respectively.CONCLUSION The drug resistance of the Mycobacteria from the patients with recurrent pulmonary tuberculosis is serious,it is necessary to execute the Mycobacteria culture and antimicrobial susceptibility testing and develop the treatment program based on the result of the drug susceptibility testing.