伤寒杆菌菌苗抗肿瘤的实验研究

Experimental study on antitumor immunity with the vaccine of salmonella typhi

应用伤寒杆菌菌苗作为疫苗对小鼠进行体内、外抗肿瘤治疗实验。结果表明腹腔注射一定剂量的伤寒杆菌菌苗在体内具有明显的抑瘤作用 ,而在体外却对多种瘤细胞无直接杀伤作用 ,提示伤寒杆菌菌苗的抑瘤作用是由机体介导的。进一步的免疫学指标显示以伤寒杆菌菌苗作为抗肿瘤疫苗可增强荷瘤小鼠的NK细胞和MΦ细胞的杀伤活性。因此证明伤寒杆菌菌苗有较强的体内抗肿瘤作用。

The vaccine of Salmonella typhi(ST) was used to the experiments of antitumor.The results showed that the vaccine of ST possessed strong activity against HcaF16A 3 and S 180 by repeated intraperoneal injection (I.P),but no direct cytotoxicity for many kinds of tumor cells with MTT assay.The result indicated that the antitumor function of ST vaccine was mediated by the host.The immunological parameters showed that ST vaccine can improve the function of NK and MΦ cells of mice bearing tumors.These results provided further evidence that the vaccine of ST possessed strong antitumor function. [WT5HZ]