SpA菌体吸收肿瘤病人血清的研究(Ⅱ、吸附有肿瘤Ig的SpA菌体对吞噬细胞吞噬功能的影响)

Study on the Serum from Tumor bearing Individual by in vitro Absorption with Staphylococcus Aureus Containing protein A(Ⅱ. Effect of protein A—containing Staphylococci absorbing Ig in the Serum of Tumor—bearing Individual on Phagocytes in vitro

我们观察了吸附有肿瘤病人血清中Ig的SpA菌体对吞噬细胞吞噬功能的影响。实验发现,小鼠腹腔巨噬细胞、正常人外周血中性粒细胞和单核细胞对吸附有肿瘤病人血清Ig的SpA菌体的吞噬(吞噬率和吞噬指数)显著高于对SpA菌体的吞噬(P<0.001)。提示吸附有肿瘤病人血清中Ig的SpA菌体所明显增强吞噬细胞的吞噬功能,此结果有助于阐明SpA菌体的体内抗瘤机制。

This paper reports the effect of protein A—containing Staphylococci absorbing Ig in the serum of tumor—bearing individual on the phagocytes in the mice and normal human PBL. in the experiments, it is discorvered that the phagocytosis of the marophages in mice, the neutrophils and mononuclears in normal human PBL on the protein A—containing Staphylococci absorbing Ig in the serum of tumor—bearing individual is significantly higher than that of on S. aureus containing protein A(phago—rate and phago—index, p<0.001). It is suggested that the protein A—containing Staphylococci absoebing Ig in the serum of tumor—bearing individual can directly increase the phagofunction of the phagocyte. Furthermore, this helps to expound the anticaneer mechanism of S. aureus containing protein A ex vivo.