2011年本院铜绿假单胞菌分布及耐药情况分析

Clinical distribution and antibiotic resistance of pseudomonas aeruginosa causing infection in our hospital in 2011

目的分析2011年本院铜绿假单胞菌(PAE)感染分布和耐药情况,为临床治疗提供依据。方法用纸片扩散法(K-B)进行药物敏感试验,对病原菌科室分布、标本来源及药敏情况进行分析。结果分离出PAE共276株,呼吸道标本最多,占84.1%,其次为伤口分泌物和尿液。在综合科、ICU、神经外科、急诊ICU及呼吸科分布较多,共占66.7%。PAE对氨曲南、替卡西林、头孢曲松和头孢噻肟的耐药率较高;对氨基糖苷类、喹诺酮类以及β内酰胺类抗生素耐药率较低。结论 PAE耐药严重,要依据药敏结果合理用药。

Objective To study the drug resistance of pseudomonas aeruginosa（PAE） causing infection in patients in 2011,to provide reference for the clinical treatment of infection with PAE.Methods The susceptibility test was performed by K-B methods.A statistic analysis was made on the results of clinical distribution and antibiotic resistance of PAE.Results Two hundred and seventy-six strains of PAE were isolated in 2011,most strains of PAE were from respiratory tract,up to 84.1%,and followed by the specimen from wound secretions and urinary tract.The PAE widely distributed in our hospital,in the synthesis section,ICU,neurosurgery ward,EICU and respiratory ward are more distributed,a total of 66.7%.Resistance rates of PAE to aminoglycosides、quinolone、piperacillin/tazobactam and cefoperazone/sulbactam were lower.Resistance rates of PAE to aztreonam,ticarcillin,ceftriaxone and cefotaxime were higher.Conclusion The drug resistance of PAE is serious,so it is of great importance to use drug in accordance with the drug susceptibility test,which is essent ial to effectively prevent the increasing drug resistance rate and the occurrence of multidrug-resistant bacteria.