特异性IgA抗体:心脑血管病慢性肺炎衣原体感染的标志

Specific immunoglobulin A: a markers of chronic chlamydia pneumoniae infection in cardiovascular and cerebrovascular diseases

目的 :探索心脑血管病慢性肺炎衣原体 ( CP)感染的血清学证据。 方法 :采用 Micro- IF检测血清特异性CP抗体。 结果 :发现约 37%心脑血管病患者血清特异性 CP- Ig A抗体水平升高 ,与献血员组 ( 3% )比差异非常显著 ( P<0 .0 1) ;特异性 CP- Ig G、CP- Ig M抗体阳性率与献血员组无显著差异 ( P>0 .0 5 )。 结论 :CP特异性 Ig A抗体与 CP慢性感染相关 ,是慢性 CP感染的标记物 ,可应用于心脑血管病慢性 CP感染 (带毒 )

Objectives: To seek serological evidence of chronic infection with chlamydia pneumoniae(CP)in cardiac and cerebral vascular diseases. Methods: Using microimmunofluorescence(MicroIF)method to determine immunoglobulin(Ig) classspecific antibodies to CP in serum. Results: 37% of the patients with cardiac and cerebral vascular diseases had elevated titers(1 in 32 or over) of serum specific CP IgA antibodies. Both frequencies were significantly higher than the controls(donors, 3%), but serum specific CPIgG and CPIgM antibodies did not differ from the controls(donors). Conclusions: An association exists between chronic CP infection and serum specific CPIgA antibodies and no association exits in serum specific CPIgG and CPIgM antibodies. Serum specific CPIgA antibodies were markers of chronic cp infection which can be used in the diagnosis and scientific research of the relationship between chronic cp infection(carrier) and cardiac or cerebral vascular and other diseases.