老年牙周炎牙龈内淋巴细胞分布的免疫组化观察

An immunohistochemical comparative study of lymphocytes in gingiva in elderly patients with periodontitis

目的 :观察老年牙周炎牙龈组织中 T和 B淋巴细胞的分布 ,并与成人牙周炎患者牙龈组织中的情况进行比较。 方法 :采用组织病理学和免疫组织化学方法 ,对 15例老年牙周炎患者和 10例成人牙周炎患者进行了 T和 B淋巴细胞分布情况的检查和比较。 结果 :老年组 Ig M阳性表达例数 ( 15例 )多于 Ig A阳性表达例数 ( 4例 ) ,而成人组则相反 ,且两组组间和组内比较差异显著 ( P<0 .0 5 )。成人组 CD4+和 CD8+细胞数明显多于老年组 ( P<0 .0 5 )。 结论 :老年牙周牙龈组织局部免疫功能降低 ,免疫调节功能紊乱 。

Objectives: To study the distribution of T and B lymphocytes in gingiva in elderly patients with periodontitis, and compared with that of adult patients. Methods: The distribution of T and B lymphocytes in gingiva were measured with histopathological and immunohistochemical methods in 15 elderly patients and 10 adult patients . Results: In elderly patients with periodontitis ,the cases of IgM positive cells in gingiva (15 cases )were more than those of IgA positive cells ( 4 cases ) ,which were contrary to the adult patients. The number of CD4+ and CD8+ lymphocytes in gingiva in adult patients was much greater than that in elderly patients (P<0.05) . Conclusions : Elderly patients with periodontitis have certain specific characteristics in immunohistochemitry , such as low immunological function in local gingiva and poor function of immunological regulation.