大面积脑梗死后出血性转化相关危险因素的临床研究

Clinical analysis of risk factors of hemorrhagic transformation in acute cerebral infarction

目的探讨大面积脑梗死后出血性转化相关危险因素。方法采用回顾性分析方法,将2006年1月～2012年1月收治的236例大面积脑梗死患者分为出血性转化组(63例)及非出血性转化组(173例),采用Logistic回归模型分析大面积脑梗死后出血性转归的危险因素。结果出血性脑梗死占同期脑梗死患者的26.7%,高血糖(OR值为2.35,95%CI7.21～12.36)和低胆固醇(OR值为2.14,95%CI3.86～5.35)是出血性脑梗死的独立危险因素。结论血糖血脂越高、临床神经功能缺损程度越重的大面积脑梗死患者越容易发生出血性转化。

Objective To explore the risk factors of hemorrhagic transformation （HT） in acute cerebral infarction. Methods The general data of 236 acute cerebral infarction patients including 63 hemorrhagic transformation patients and 173 non- hemorrhagic transformation （NHT） patients were analyzed retrospectively. Logistic regression analysis was used to explore the risk factors of hemorrhagic transformation. Results There were 26.7 percentage of acute cerebral infarction patients had hemorrhagic transformation. Logistic regression analysis showed that blood sugar （OR was 2.35, 95%CI 7.21-12.36） and TC （OR was 2.14, 95%CI 3.86-5.35） were independent risk factors of HT. Conclusion The serum level of blood sugar and TC are the major risk factors of HT in acute cerebral infarction.