酚苄明对淋巴液抗休克作用的影响

The Effect of Phenoxybenzamine on Anti_shock of Lymph

目的探讨肠淋巴液对失血性休克的抗休克作用与肾上腺素能α受体的关系。方法45只失血性休克大鼠分为三组 :酚苄明(POB)组、单纯淋巴液治疗组及生理盐水对照组。POB组放血后以POB阻断α -肾上腺素能受体。前2组给予小量肠淋巴液及输血后观察存活时间及血压 ,对照组以生理盐水代替肠淋巴液。结果POB组与单纯淋巴液治疗组比较的存活率分别为53.33%和46.67% ,均显著高于生理盐水对照组(P<0.05) ,但POB组的血压显著低于单纯淋巴液治疗组(P<0.05) ,与生理盐水对照组无显著性差异(P>0.05)。

Objective To study the relationship between the anti_shock effect of lymph and alpha adrenoceptor. Methods 45 rats with hemorrhagic shock were divided into three groups:the POB group, the simple lymph treated group, and normal saline control group. In POB group, the alpha adrenoceptor of rats were blocked with phenoxybenzamine (POB) after blood loss. After the administration with a little of intestinal lymph and blood infusion in the anterior two groups, the survival time and blood pressure were observed. The normal saline replaced the intestinal lymph in control group. Results The survival rates of POB group and the simple lymph treated group were 53.33% and 46.67% respectively, which were significantly higher than that of normal saline group (P<0.05). But the blood pressure of POB group was significantly lower than the simple lymph treated group (P<0.05),and showed no statisical difference compared with the normal saline group(P>0.05). Conclusion The anti_shock effect of lymph may not be played through alpha adrenoceptor.