三芪参胶囊对肾病综合征血脂、血液流变学及疗效的影响

Influence of Sanqishan Capsule on, Lipid, Hemorrheology and Therapeutic Effect in Patients with Nephrotic Syndrome

目的探讨三芪参胶囊对肾病综合征血脂、血液流变学及疗效的影响。方法97例服用强的松的肾病综合征患者 ,随机分为对照驵、治疗组。治疗组每天加服三芪参胶囊三次 ,每次三粒 ,连服30d ,检测治疗前后的血脂、血液流变学、有效肾血流量、肾功能和24h尿蛋白定量等指标。结果对照组只有全血低切粘度、血沉、血清肌酐和24h尿蛋白定量于观察结束后有显著性改善(P<0.05或P<0.01) ,其它指标无显著改善。总有效率为77.8 %。治疗组各项观察指标于观察结束后明显改善(P<0.05或<0.01) ,其总有效率达92.3% ,与对照组比较有显著性差异(P<0.05或P<0.01)。结论三芪参胶囊可降低肾病综合征患者的血脂 ,改善血液流变学指标和肾内微循环的血液灌流 。

Objective To investigate influence of Sanqishan capsule on lipid, hemorrheology and therapeutic effect in patients with nephrotic syndrome. Methods 97 cases of nephrotic syndrome with glucocorticoid therapeutics were divided randomly into control and treatment groups. Three Sanqishan capsules were taken three times daily in treatment group while in control group using glucocorticoid only, the experiment lasted 30 days. Before and after treatment, serum lipid, hemorrheology, effective renal plasma flow, serum creatine and 24 hours urine protein qantity were determined. Results In the control group,After thirty days low shearing rate viscosity of blood, ESR,Scr and 24hrUPQ improved significantly(P<0.05 or P<0.01).Total effective rate was 77.8%。In the treatment group, All indexes improved markedly after therapy(P<0.05 or P<0.01),total effective rate was 92.3%. There was significant difference as compared with that of the control group after therapy(P<0.05P&P<0.01). Conclusion The study shows Sanqishan capsule can reduce lipid, improve hemorrheology and blood flow in renal microcirculation, which has better therapeutic efficacy for the patients with nephrotic syndrome.