摘要
对聚乙交酯纤维和聚丙交酯纤维进行体外降解和细胞接种试验,研究两种纤维的体外降解行为,观察细胞在两种纤维上的黏附情况。研究结果表明:聚乙交酯纤维适合细胞的黏附和增殖,但是其降解速度较快;而聚丙交酯纤维的降解速率较慢,但是细胞在纤维上的黏附和增殖情况较差。根据两种纤维的特性,设计了一种具有皮芯结构的新型纤维基组织工程肌腱支架,既能为细胞黏附提供场所,还能在降解中承担一定的力学载荷。
The behaviors of polyglycolide(PGA)fibers and polylactide(PLA)fibers during degradation in vitro and the morphology of the fibers with cells were investigated.Results showed that the PLA fibers could keep much more tensile strength during degradation in vitro than the PGA fibers.However,cell attachment and proliferation on the PGA fibers were better than on the PLA fibers.According to the properties of two kinds of fibers,a novel fiber based scaffold with a skin-core structure for tendon tissue engineering was designed,which could provide a place for cell attachment and mechanical strength during degradation.
出处
《河南科技大学学报（自然科学版）》
CAS
北大核心
2012年第6期11-14,4-5,共4页
Journal of Henan University of Science And Technology:Natural Science
基金
河南省基础与前沿技术研究计划基金项目(112300413225)
关键词
聚乙交酯
聚丙交酯
纤维
支架
降解
Polyglycolide
Polylactide
Fiber
Scaffold
Degradation
