摘要
目的:检测缺氧诱导因子-1α(HIF-1α)和环氧合酶-2(COX-2)在尖锐湿疣组织中的表达。方法:采用免疫组化SP法检测30例尖锐湿疣组织和20例包皮组织中HIF-1α和COX-2的表达。结果:尖锐湿疣组织中HIF-1α和COX-2的阳性表达率及阳性表达强度均显著高于正常对照组(均P<0.01),尖锐湿疣组织中HIF-1α与COX-2的表达呈正相关。结论:尖锐湿疣组织的过度增殖可能与组织中HIF-1α和COX-2的异常表达有关。
Objective: To detect the expression of hypoxia inducible factor- 1α(HIF- 1α) and cyclooxygenase - 2 (COX- 2) in condyloma acuminatum (CA). Methods: Immunohistochemistry streptavidin- peroxidase method was performed to detect the expression of HIF - 1α and COX - 2 in tissue specimens from CA lesions of 30 patients and foreskin of 20 normal human controls. Results: The positivity rates and the expression intensity of HIF- 1α and COX - 2 were significantly higher in CA than in normal controls ( P 〈 0. 01). There was a positive correlation be- tween the expression of HIF- 1α and COX- 2 in CA ( P 〈 0.01). Condusion: The over- proliferation of lesions in CA may be related to the abnormal expression of HIF - 1α and COX - 2.
出处
《中国麻风皮肤病杂志》
2012年第10期690-692,共3页
China Journal of Leprosy and Skin Diseases