缺氧诱导因子-1α和环氧合酶-2在尖锐湿疣中的表达

Expression of hypoxia inducible factor-1α and cyclooxygenase- 2 in condyloma acuminatum

目的:检测缺氧诱导因子-1α(HIF-1α)和环氧合酶-2(COX-2)在尖锐湿疣组织中的表达。方法:采用免疫组化SP法检测30例尖锐湿疣组织和20例包皮组织中HIF-1α和COX-2的表达。结果:尖锐湿疣组织中HIF-1α和COX-2的阳性表达率及阳性表达强度均显著高于正常对照组(均P<0.01),尖锐湿疣组织中HIF-1α与COX-2的表达呈正相关。结论:尖锐湿疣组织的过度增殖可能与组织中HIF-1α和COX-2的异常表达有关。

Objective： To detect the expression of hypoxia inducible factor- 1α（HIF- 1α） and cyclooxygenase - 2 （COX- 2） in condyloma acuminatum （CA）. Methods： Immunohistochemistry streptavidin- peroxidase method was performed to detect the expression of HIF - 1α and COX - 2 in tissue specimens from CA lesions of 30 patients and foreskin of 20 normal human controls. Results： The positivity rates and the expression intensity of HIF- 1α and COX - 2 were significantly higher in CA than in normal controls （ P 〈 0. 01）. There was a positive correlation be- tween the expression of HIF- 1α and COX- 2 in CA （ P 〈 0.01）. Condusion： The over- proliferation of lesions in CA may be related to the abnormal expression of HIF - 1α and COX - 2.