摘要
miR-205在多种肿瘤中存在差异性表达，与肿瘤的发生发展及转移等过程密切相关。miR-205可通过与特定靶基因结合参与调控肿瘤细胞的增殖、分化、原位侵袭及远处转移等生物学行为。对miR．205的深入研究，有望对肿瘤的诊断、靶向治疗及预后等发挥重要作用。
miR-205 is differentially expressed in tumor tissues and is closely related to tumorigenesis and tumor metastasis, miR-205 can regulate the biological behaviors of tumor cells such as cell proliferation, differentiation, in situ invasion and distant metastasis by post-transcriptional regulation through binding to targe- ted genes. Additionally, further research of miR-205 may be helpful for tumor diagnosis, targeted therapy and prognosis.
出处
《国际肿瘤学杂志》
CAS
2012年第10期732-734,共3页
Journal of International Oncology
基金
山东省科技攻关项目（2008GGl0002058）
