血必净对脑梗死合并全身炎症反应综合征的治疗作用及影响

Therapeutic action and effects of xuebijing to cerebral infarction with systemic inflammatory response syndrome

目的探讨血必净对脑梗死合并全身炎症反应综合征的治疗作用及对炎性因子、C反应蛋白和肝肾功能的影响。方法我院2009年5月-2012年5月收治的脑梗死合并全身炎症反应综合征患者63例,随机分为治疗组和对照组,对照组予常规治疗,治疗组在常规治疗的基础上予血必净注射液100 mL,2次/d,疗程10d。比较治疗前后两组的临床疗效,检测肿瘤坏死因子(TNF)-2α、白细胞介素(IL)-6、IL-8水平变化。结果治疗组总有效率为93.75%,对照组总有效率为64.52%,两组比较,差异有统计学意义(P<0.05)。TNF-2α、IL-6、IL-8、CRP水平明显下降(P<0.05),AST、ALT、Cr水平明显降低(P<0.05)。结论血必净可改善脑梗死合并全身炎性反应且治疗后肝肾功能均有明显改善。

Objective To discuss the therapeutic effect of xuebijing to cerebral infarction with SIRS,and observe the influence on inflammatory factor C-reactive protein, liver and kidney function. Methods 63 patients, who suffered from cerebral infarction with SIRS in our hospital, from May 2009 to May 2012. Patients were randomly divided into treatment group and control group. Basing on the conventional therapy（ control group）, treatment group was in- jected xuebijing 100 mL,twice dally,the treatment course was 10 d. The clinical effects before and after the treatment were compared, the levels of blood tumor necrosis factor（TNF）-2α, IL-6 and IL-8 were detected. Results The effective rate of treatment group and control group were 93.75% and 64. 52% respectively （P 〈 0. 05 ）. and the level of TNF-2α, IL-6, IL-8 CRP, AST, ALT and Cr decreased（ P 〈 0. 05 ）. Conclusion Xuebijing has good efficacy on cerebral infaction with SIRS, and it can improve liver and kidney function.