临床药师参与卡培他滨致腹泻一例

Pharmaceutical care of a patient with capecitabine due to diarrhea

目的加强药学监护,降低抗肿瘤药不良反应的发生率。方法针对1例结肠癌复发转移患者,观察其入院治疗用药监护情况。结果患者入院后行卡培他滨联合奥沙利铂(XELOX)化学治疗后,出现Ⅲ度顽固性腹泻。临床药师在治疗过程中密切观察病情变化,及时发现不良反应并建议医生给予洛哌丁胺止泻、醋酸奥曲肽对症治疗后,患者最终症状缓解出院。结论药学监护可以降低抗肿瘤药不良反应的发生率,明显提高患者治疗的依从性。

Objective To reduce the incidence of adverse drug reactions induced by antineoplastic drugs by pharmaceutical care. Methods A patient with colon cancer recurrence and metastasis was chose, and the hospitalized medication was observed. Results III degree of intractable diarrhea appeared after capecitabine and Oxaliplatin （ XE- LOX） treatment. Clinical pharmacists observed the changes of patient＇s condition and detected the adverse reaction timely. Pharmacists suggested that doctors should give loperamide and octreotide acetate to symptomatic treatment. At last, the symptom was relieved, and the patient was discharged. Conclusion Pharmaceutical care can reduce the incidence of the adverse drug reactions induced by antineoplastic drugs, and improve the compliance of the patients obviously.