高同型半胱氨酸血症与脑梗死复发的相关性分析

Study on correlation between hyperhomocysteinemia and recurrence of cerebral infarction

目的探讨高同型半胱氨酸血症(Hhcy)与脑梗死复发的关系。方法对90例脑梗死患者随访3年,其中45例脑梗死复发患者为观察组和45例无复发的脑梗死为对照组,回顾性分析入院时血浆同型半胱氨酸(Hcy)水平及各组中Hhcy患者发生率,分析Hhcy与脑梗死复发的关系。结果脑梗死复发组血浆Hcy水平明显高于对照组,两者差异有显著的统计学意义(P<0.05)。比较两组复发发病率及病死率,两者差异有显著的统计学意义(P<0.05)。结论同型半胱氨酸增高为脑梗死及脑梗死复发的高危因素,血浆Hcy可作为对有脑血管病倾向的人群常规检查指标,对预防复发、对指导治疗脑血管病有积极意义。

Objective To explore the relationship between high homocystinemia （ Hhcy ） and recurrence of cerebral infarction. Methods Forty five patients with recurrence of cerebral infarction were allocated in observation group and 45 patients with cerebral infarction without recur- rence were assigned to control group, and these 90 patients with cerebral infarction were followed up for 3 years. The data of plasma level of hyper- homocysteinemia （Hcy） and incidence rate of Hcy in patients of each group were retrospectively analyzed and the relationship between Hhcy and recurrence of cerebral infarction was studied. Results The plasma Hcy level in patients of recurrent cerebral infarction group was significantly higher than that of control group, their difference was statistically significant （ P 〈 0.05 ）. On the basis of result of Hcy during admission, they were divided into Hhcy group and Nhcy group, the recurrence rate and mortality were compared between these two groups, and their difference was statistically significant （ P 〈 0.05 ）. Conclusion The increased level of homocysteine is a risk factor for patients with cerebral infarction and re- currence of cerebral infarction, and plasma level of Hcy can be used as a routine indicator in survey of population with trend of having cerebrovas- cular disease, and it has positive significance in guidance of treatment for patients with cerebrevascular disease and prevention for its recurrence.