人前心钠肽在肝病诊断中的价值

Signif icance of serum levels of pro-atrial natriuretic peptide in patients with liver diseases

目的:检测肝病患者血清中人前心钠肽(proatrial natriuretic peptide,proANP)水平,评价proANP在肝病患者中的诊断价值.方法:收集我院住院患者中肝功能检查异常的、经临床和实验室检查证实无细菌感染患者血清32例(其中肝硬化13例、原发性肝癌12例、药物性肝炎3例、慢性重度乙型肝炎4例)作观察组,选择20例来我院作健康体检的成人血清作对照组,同时进行proANP检测.结果:正常对照组成人血清proANP浓度分别与肝硬化组、原发性肝癌组、药物性肝炎组和慢性重度乙型肝炎组患者血清proANP浓度比较,均有显著性差异(t=8.970,9.088,3.826,8.240,均P<0.001).各肝病组间进行比较,慢性重度乙型肝炎组与其他3组比较差异有显著性,其余各组间差异无显著性.结论:血清中proANP水平增高,对多种肝病患者的诊断具有一定的诊断价值.

AIM： To evaluate the diagnostic significance of serum levels of pro-atrial natriuretic peptide （pro-ANP） in patients with liver diseases. METHODS： Serum samples collected from 32 hospitalized patients with abnormal liver func- tion test results （including 13 patients with cir- rhosis, 12 patients with hepatocellular carcino- ma, 3 patients with drug-induced hepatitis, and 4 patients with chronic severe hepatitis B） and 20 healthy adults were used in this study. The levels of serum pro-ANP were detected. RESULTS： Compared to healthy adults, serum levels of pro-ANP were significantly higher in patients with cirrhosis, hepatocellular carcino- ma, drug-induced hepatitis, and chronic severehepatitis B （t = 8.970, 9.088, 3.826, 8.240, all P 〈 0.001）. Serum levels of pro-ANP were also sig- nificantly higher in patients with chronic severe hepatitis B than in those with cirrhosis, hepato- cellular carcinoma, drug-induced hepatitis, but showed no significant differences among the other three groups of patients. CONCLUSION： Increased serum pro-ANP lev- els have a diagnostic value in patients with vari- ous liver diseases.