PCT、hs-CRP和血小板在新生儿败血症诊断中的价值及与病情的关系

Diagnostic value of PCT,hs -CRP and platelet in neonatal septicemia and their relationship with disease condition

目的探讨血清降钙素原(PCT)、超敏C-反应蛋白(hs-CRP)和血小板在新生儿败血症诊断中的价值及与病情的关系。方法对我院住院治疗的66例新生儿败血症患者临床资料进行回顾性分析,选择同期60例健康新生儿为对照组。比较两组血清PCT、hs-CRP和血小板的水平,计算三者诊断新生儿败血症的敏感性、特异性。结果败血症组患儿PCT及hs-CRP水平显著升高(P<0.05),血小板水平显著下降(P<0.05);PCT、hs-CRP和血小板诊断新生儿败血症的敏感性分别为84.8%、69.7%和53.0%,特异性为75.0%、50.0%和22.5%;败血症组患儿恢复期PCT及hs-CRP水平显著降低,血小板水平显著升高,与疾病初期相比差异具有统计学意义(P<0.05)。结论 PCT、hs-CRP和血小板对新生儿败血症具有诊断意义,能较好地反应患儿病情变化。

Objective To explore the diagnostic value of PCT, hs-CRP and platelet in neonatal septicemia and their relationship with disease condition, Methods A total of 66 cases with neonatal septicemia were retrospectively analyzed. 60 cases of healthy neonates were selected as control group. PCT, hs-CRP and platelet between two groups were compared, and the sensitivities and specificities for neonatal septicemia were studied. Results Compared with control group, PCT and hs-CRP greatly increased and platelet decreased in neonatal septicemia group （P 〈 0.05）; The sensitivities were 84.8%, 69.7% and 53.0% and the speeificities were 75.0%, 50.0% and 22.5% for PCT, hs-CRP and platelet. Compared with initial stage, PCT and hs-CRP increased and platelet decreased greatly in recovery stage （P 〈 0.05）. Conclusion PCT, hs-CRP and platelet have significant diagnostic values for neonatal septicemia. They are valuable for evaluating the disease condition.