乌司他丁联合丹红注射液治疗重症急性胰腺炎的疗效分析

The efficacy of ulinastatin joint Danhong injection in the treatment of severe acute pancreatitis

目的观察乌司他丁联合丹红注射液治疗重症急性胰腺炎的临床疗效。方法选择2010年1月～2012年1月在我院住院治疗的60例确诊的重症急性胰腺炎患者作为入选对象，全部患者随机分为观察组和对照组各30例，两组均予心电监护、禁食、胃肠减压、吸氧、补液、维持水和电解质及酸碱平衡、改善血流动力学、抗生素防治感染、营养支持等对症支持治疗；观察组在次基础上予丹红注射液20～40mL加入0．9％生理盐水250～500mL稀释后缓慢静滴．乌司他丁20mg＋生理盐水100mL缓慢静滴，每日3次。结果观察组治疗后无效仅3例，总有效率为90．0％（27/30），对照组无效8例，总有效率为73．3％（22／30），观察组总有效率明显高于对照组，差异有统计学意义（P〈0．05）。观察组腹痛和腹胀的缓解时间、首次排便时间、住院时间均明显短于对照组，差异有统计学意义（P〈0．05或P〈0．01）。两组患者治疗前血淀粉酶比较，无显著差异，治疗后均较治疗前降低，且观察组治疗后血淀粉酶水平明显低于对照组．差异有统计学意义（P〈0．05）。结论乌司他丁联合丹红注射液治疗重症急性胰腺炎疗效确切，安全性好，值得临床推广和应用。

Objective To outlook Ulinastatin joint Danhong injection treatment of severe acute pancreatitis of the efficacy. Methods The treatment of 60 cases of confirmed severe acute pancreatitis in our hospital from January 2010 to January 2012 as the selected object, all patients were randomly divided into observation group and control group, each 30 cases, groups were treated ECG monitoring, fasting, decompression, oxygen, rehydration, maintenance of water, electrolyte and acid-base balance, improve hemodynamics, antibiotics prevent infection, nutritional support, symptomatic and supportive treatment. Again on the basis of observation group to Danhong injection 20-40 mL 0.9% saline 250-500 mL diluted slow intravenous infusion of ulinastatin 20 mg＋100 mL normal saline slow intravenous infusion three times a day. Results The observation group after treatment ineffective in only three cases, the total effective rate was 90.0% （27/30）, the control group, 8 cases, total effective rate was 73.3% （22/30）, the observation group, the total efficiency was significantly higher than con- trol group, the difference was statistically significant （P 〈 0.05）. The observation group abdominal pain, bloating relief time, time to first bowel movement, length of hospital stay were significantly shorter in the control group, the difference was statistically significant （P 〈 0.05 or P 〈 0.01）. The two groups before treatment blood amylase comparison, the difference was not significant, lower than those before treatment after treatment and observation group after treatment, serum amylase level was significantly lower than the control group, the difference was statistically significant （P 〈 0.05）. Conclusion The effect of the ulinastatin joint Danhong injection treatment of severe acute pancreatitis, security, worthy of promotion and application.