重组人干扰素-γ联合激素治疗特发性肺间质纤维化30例

IFN-γ combined with hormone for idiopathic pulmonary fibrosis:A study of 30 cases

目的探讨重组人干扰素-γ联合激素治疗特发性肺间质纤维化的临床疗效。方法选择2009年1月～2012年1月在我院治疗的特发性肺间质纤维化患者60例为研究对象,随机分为联合组和激素组,同时选择健康体检者30例为对照组,比较联合组和激素组治疗前后临床症状情况,检测肺间质纤维化患者与对照组的血清胶原蛋白与透明质酸的水平。结果在刺激性干咳、呼吸困难、活动能力、肺弥散功能方面,两组好转比例差异有高度统计学意义(P<0.01)。治疗前,特发性肺纤维化患者血清纤维化指标显著高于对照组(P<0.01),而联合组和激素组之间差异无统计学意义(P>0.05);治疗后,联合组血清纤维化指标下降程度高于激素组(P<0.01)。结论联合重组人IFN-γ和激素治疗特发性肺间质纤维化,可以延缓患者肺间质纤维化的进程,减轻患者的症状和体征。

Objective To discuss the clinical efficacy of IFN-γ combined with hormone for IPF. Methods Selected 60 cases with IPF from Jan 2009 to Jan 2012 were divided into combined group and hormone group. 30 healthy people were selected as control group. Clinical efficacy of two groups were compared, and Serum collagen and hyaluronic acid level of three groups were detected. Results Improved ration of Irritating cough, dyspnea, activity of daily living, pulmonary diffu sion function in combined group were more than control group （P 〈 0.01 ）. Serum fibrosis indices in IPF were higher than control before treatment （P 〈 0.01 ）, and no significant difference between combined group and hormone group （P 〉 0.05 ）. After treatment, serum fibrosis indices in combined group decreased more than hormone group （P 〈 0.01 ）. Conclusion IFN-γ combined with hormone in treatment of IPF can defer idiopathic pulmonary fibrosis, release symptom and sign.