糖尿病合并高血压患者发生视网膜病变的危险因素分析

Analysis of the risk factors of diabetic hypertensive patients with retinopathy

目的探讨高血压对糖尿病患者发生视网膜病变(DR)的影响及糖尿病高血压患者发生DR的危险因素。方法研究732例糖尿病患者血压及DR相关因素,分析不同血压对糖尿病患者发生DR的影响,单因素和多因素分析糖尿病高血压患者发生DR的危险因素。结果高血压组DR患病率显著高于对照组(P<0.01),糖尿病高血压患者不同收缩压及舒张压范围DR、NPDR、PDR患病率差异显著(P<0.01),收缩压、舒张压与DR患病率均呈正相关(P<0.05)。收缩压、教育程度、吸烟、糖尿病周围神经病变、糖尿病肾病、HbA1c、血脂异常是糖尿病高血压患者发生DR的危险因素(P<0.05)。结论高血压显著加剧糖尿病发生DR风险,收缩压、教育程度、吸烟、糖尿病周围神经病变、糖尿病肾病、HbA1c、血脂异常与糖尿病高血压患者发生DR密切相关。

Objective To investigate the impact of hypertension on retinopathy in diabetic patients, and the risk factors of diabetic hypertension patients with retinopathy. Methods Blood pressure .and retinopathy-related factors of 732 cases of diabetic patients were studied, and the impact of different blood pressure on DR in diabetic patients was analyzed, univariate and multivariate analysis of risk factors for diabetic hypertensive patients with retinopathy were done. Results The prevalence of DR in hypertension group was significantly higher （P 〈 0.01）, systolic and diastolic blood pressure range DR, NPDR, PDR prevalence of diabetic patients with hypertension were significantly different （P 〈 0.01）, systolic blood pressure, diastolic blood pressure and DR prevalence were positively correlated （P 〈 0.05）. Systolic blood pressure, education level, smoking, diabetic peripheral neuropathy, diabetic nephropathy, HbA1c, dyslipidemia were the risk factors of diabetic hypertensive patients with DR （P 〈 0.05）. Conclusion Hypertension significantly exacerbate diabetes DR risk, and systolic blood pressure, education level, smoking, diabetic peripheral neuropathy, diabetic nephropathy, HbA1c, dyslipidemia are closely related with DR in diabetic hypertensive patients.