外周血细胞淋巴亚群检测对噬血细胞综合征患者免疫功能评估的意义

Significance of lymphocyte subset analysis in peripheral blood in evaluation of immunological function in patients with HPS

目的探讨外周血细胞淋巴亚群检测对噬血细胞综合征(hemophagocytic syndrome,HPS)患者免疫功能状态评估的意义,为临床正确诊断、及早干预HPS进展提供依据。方法对本院2001年1月～2012年5月出院诊断为HPS的患者82例的外周血细胞亚群结果进行回顾性分析。结果 HPS患者NK细胞百分比明显低于健康对照组,差异有统计学意义(P<0.05);感染相关性HPS CD4+、CD4+/CD8+比值较非感染相关性HPS及健康对照者明显降低、CD8+明显升高,差异有统计学意义(P<0.05)。结论 HPS患者NK细胞活性下降,存在细胞和体液免疫功能异常,临床检测HPS患者外周血淋巴亚群水平对HPS免疫功能状态的正确评估和早期干预有重要价值。

Objective To explore the significance of lymphocyte subset analysis in peripheral blood in evaluation of immunological function in patients with HPS, in order to provide evidences of diagnosis and to interfere in the evolvement of HPS as soon as possible. Methods We carried on retrospectives analysis of the lymphocyte subset of 82 patients with HPS, who received treatments in our hospital from Jan.2001 to May 2012. Results The percentage of natural killer cell （NK cell） of patients with HPS was obviously lower than the healthy（P 〈 0.05）; CD4＋ and the ratio of CD4＋/CD8＋ in patients with infective induced HPS was obviously lower than the non-infective induced HPS and the healthy （P 〈 0.05）, but CD8＋was obviously increased（P 〈 0.05）. Conclusion The activity of NK ceils in patients with HPS deceased obviously. The analysis of lymphocyte subset in peripheral blood cells is helpful to correctly evaluate the immune function and interfere at early time in patients with HPS. nction