利培酮联合高压氧治疗颅脑损伤伴发精神障碍的疗效分析

Clinical evaluation of risperidone combining with hyperbaric oxygenation treatment on patients with psychotic disorder after traumatic brain injury

目的观察利培酮联合高压氧治疗颅脑损伤伴发早期精神障碍的治疗效果。方法 44例颅脑损伤伴发早期精神障碍患者随机分为利培酮组与利培酮联合高压氧组,所有患者在神经外科常规治疗的基础上,应用利培酮治疗8周,而利培酮联合高压氧组患者在应用利培酮治疗同时行高压氧治疗,使用简明精神病评定量表(BPRS)来评定治疗前、治疗后第2周、第4周及第8周的治疗效果。结果两组BPRS评分在治疗后第2周及第4周较治疗前减少,但两组间无统计学意义,在治疗后第8周两组BPRS评分较治疗前明显减少,两组间BPRS评分有显著性差异(P<0.01)。结论应用利培酮联合高压氧治疗颅脑损伤伴发早期精神障碍的疗效明显好于单纯应用利培酮治疗。

Objective To investigate the therapetic effect of risperidone combining with hyperbaric oxygenation treatment on patients with pychotic disorder after traumatic brain injury. Methods A total of 44 patients with psychotic disorder after traumatic brain injury were randomly assigned to risperidone therapy group and risperidone combining with hyperbaric oxygenation therapy group,all of whom received the same routine therapy.The risperidone group were treated by risperidone with course of 8 weeks, another group were treated by risperidone combining with hyperbaric oxygenation. The brief psychiatric rating scale （BPRS） had been adopted for evaluating the therapetic effect before treatment and in the 2nd, 4th, 8th weeks after the treatment. Results The BPRS scores of the two groups are almost the same in the 2nd,4th weeks after the treatment. The BPRS scores of the two groups after 8 weeks treatment were both significantly declined than that before treatment with significant differences （P 〈 0.01 ）. Conclusion Risperidone combining with hyperbaric oxygenation treat merit were significantly better than risperidone treatment on patients with pychotic disorder after traumatic brain injury.