白介素-10基因多态性与肠易激综合征易感性关系的Meta分析

Association between interleukin-10 gene polymorphisms and susceptibility to irritable bowel syndrome:A meta-analysis

目的:评价白细胞介素-10(interleukin-10,IL-10)基因多态性与肠易激综合征(irritable bowel syndrome,IBS)遗传易感性的关系.方法:检索PubMed、EMBASE数据库、Cochrane图书馆(1966/2011-12)、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库(1979/2011-12).应用RevMan5.0对各研究结果进行异质性检验和效应值合并.结果:8篇文献被纳入分析,其中涉及IL-10-592多态性的文献4篇、IL-10-819多态性的文献4篇、IL-10-1082多态性的文献7篇.-592位点A等位基因的OR值为1.26,95%CI:1.03-1.54,P=0.02;-592位点AA型基因的OR值为1.67,95%CI:0.71-3.93,P=0.24;-819位点T等位基因的OR值为1.24,95%CI:1.02-1.52,P=0.03;-819位点TT型基因的OR值为1.31,95%CI:0.59-2.91,P=0.50;-1082位点G等位基因的OR值为1.00,95%CI:0.86-1.17,P=0.98;-1082位点GG型基因的OR值为0.68,95%CI:0.51-0.92,P=0.01.分层分析显示:西方人种-1082位点GG型基因的OR值为0.71,95%CI:0.52-0.97,P=0.03;东方人种-1082位点GG型基因的OR值为0.42,95%CI:0.13-1.31,P=0.13.结论:西方人种-1082位点GG型基因与IBS遗传易感性相关,-592位点A等位基因和-819位点T等位基因可能会增加东方人种患IBS的危险性.

AIM：To investigate the association between interleukin-10 （IL-10） gene polymorphisms and genetic susceptibility to irritable bowel syndrome （IBS）. METHODS：Published work involving IBS from PubMed, EMBASE, Cochrane library in English and from China Academic Journal, Chinese Bio-Medical Literature Database, Wanfang Database in Chinese were searched for relevant articles. Correlation analysis was performed using RevMan 5.0. RESULTS：Seven studies were finally accepted for analysis. There were four studies focused on IL-10-592 polymorphism, four studies on IL-10-819 polymorphism, and seven studies on IL-10-1082 polymorphism. The odds ratio （OR） was 1.26 （95% CI：1.03-1.54, P = 0.02） for the -592 A allele, 1.67 （95% CI：0.71-3.93, P = 0.24） for -592 AA genotype, 1.24 （95% CI：1.02-1.52, P = 0.03） for the -819 T allele, 1.31 （95% CI：0.59-2.91, P = 0.50） for -819 TT genotype, 1.00 （95% CI：0.86-1.17, P = 0.98） for the -1082 G allele, and 0.68 （95% CI：0.51-0.92, P = 0.01） for -1082 GG genotype. Subgroup analysis showed that the OR of -1082 GG was 0.71 （95% CI：0.52-0.97, P = 0.03） in Western population, and 0.42 （95% CI：0.13-1.31, P = 0.13） in the Eastern population. CONCLUSION：Our meta-analysis suggests that the -1082 GG genotype is a risk factor for IBS in Western people, and the -592 A allele and -819 T allele might be risk factors for IBS in Eastern people.