快速眼球运动睡眠行为障碍与帕金森病的相关性研究

Correlation study on rapid eye movement sleep behavior disorder and Parkinson's disease

目的研究快速眼球运动睡眠行为障碍(RBD)与帕金森病(PD)的相关关系,并探讨伴有RBD的PD患者的临床特征。方法选择我院106例PD患者,根据非运动症状问卷(NMS quest)第25项问答结果,将入选的84例患者分为RBD组(54例)和非RBD组(30例),采用统一PD评分量表(UPDRS)、Hoehn-Yahr(H-Y)分级比较两组患者的运动症状,选用NMS quest量表比较两组非运动症状发生情况,选用简易精神状态检查法(MMSE)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、帕金森病睡眠量表(PDSS)和Epworth嗜睡量表(ESS)对两组患者的认知功能、焦虑和抑郁、睡眠障碍进行比较。结果 RBD组患者的病程[(3.7±1.3)年]显著短于非RBD组[(5.1±2.2)年](P<0.05),RBD组与非RBD组运动症状比较差异无统计学意义(P>0.05);RBD组的非运动症状(胃肠道功能、自主神经系统功能、精神和睡眠活动等)的发生率显著高于非RBD组(P<0.05)。结论伴发RBD的PD患者的病程较短,非运动系统受累的临床症状更加广泛。

Objective To study the correlation of rapid eye movement sleep behavior disorder（RBD） and Parkinson＇s disease（PD）,and the clinical manifestations of RBD patients with PD.Methods 106 cases of patients with PD were included into this study,they were divided into the RBD group and non RBD group according to their answers to 25th question of the non motor symptoms questionnaire（NMS quest）.Then the motor clinical symptoms were compared between PD patients with RBD and without RBD using the scores of unified Parkinson＇s disease rating scale（UPDRS） and Hoehn-Yahr（H-Y） stage,and the dysfunctions of non motor symptoms were compared between PD patients with RBD and without RBD using NMS quest.The cognitive impairment,anxiety,depression and sleep disorders were compared using the evaluation tools of non motor functions including mini mental state exam（MMSE）,Hamilton depression scale（HAMD）,Parkins＇s disease sleep scale（PDSS） and Epworth sleepiness scale（ESS）.Results The course of the disease in RBD group [（3.7±1.3） years] was significantly shorter than non RBD group [（5.1±2.2）years]（P 0.05）,the motor clinical symptoms were showed no statistical difference between RBD and non RBD group.The non motor symptoms,including the gastrointestinal dysfunctions,autonomic dysfunctions,mood disorders and sleep disturbances,were found more frequently in RBD group than non RBD group.Conclusion The course of PD patients with RBD is short,and it has a tendency to suffer from dysfunction of non motor systems.